Basic Information
VIS ID
TVIS10007296
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1157
Orient
-
Integrated sequence
GCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCC| |CGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTC
Host Sequence
Chromosome
chr4
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
161348938/160427786 (Hg38)
End
161348938/160427786 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1298892; hsa-mir-1305/Downstream/2665788;
Nearest TSS
ENST00000502981/Upstream/650002; ENST00000512652/Downstream/111468;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1323803, chr4-CpG: 71/Downstream/2738523
Nearby gene
RAPGEF2(-1067637) ; FSTL5(+956106) ;
Upstream sequence
ATAAAACAGCACTTTGTTTTTATCTCCTGCTCTATTGTGCCATACTGTTAAATGTTTATAATGCCTGTTCTGTTTCCAAATTTGTGATGCTTATGAATAT
Downstream sequence
TTCCTGGAGACAATATATGACAATGGTTTGGGATATACATTAACAGTTGATTTAGGAAATGTCAAAGATAACTGAGTTGGGAGCTGGAAAGTAATCATGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate