Basic Information
VIS ID
TVIS10007298
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
900
Orient
+
Integrated sequence
GTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTT| |ATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAAT
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
191043856/190122701 (Hg38)
End
191043856/190122701 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5184261;
Nearest TSS
ENST00000502981/Upstream/58199; ENST00000616166/Downstream/51073;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/30247, chr4-CpG: 24/Downstream/50432
Nearby gene
DUX4L2(-30380) ;
Upstream sequence
TATATGGCTATAGTAATAGCTATATTAACATATCTTTTATATTTCACATTATACATACATTTTCTATTAATGTCTATATGAGCATCTATATTGTGTGTCT
Downstream sequence
ttagggttagggttggggttggggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttgggttagggttggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate