Basic Information
VIS ID
TVIS10007301
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3006
Orient
+
Integrated sequence
GATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCG| |GGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCAC
Host Sequence
Chromosome
chr4
Cytoband
p11
Reference genome
GRCh37/hg19
Start
49129026/49127009 (Hg38)
End
49129026/49127009 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1474266; hsa-mir-1243/Downstream/3585673;
Nearest TSS
ENST00000502981/Upstream/98317; ENST00000504661/Downstream/2715991;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/140218, chr4-CpG: 24/Downstream/34431
Nearby gene
CWH43(-64931) ;
Upstream sequence
tgcatagtgtggtaaaaaaatgtaaggatATACTATGGCAATTCTATTTCTTTTTTATTTTATGCCATTCATTTTGAGCTGCCCCTTCTCTAAATACATA
Downstream sequence
ccactcgggttgattccattcctttccattccattccattccattccattccattccattccattccattccattccattgcattccattccattccata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate