Basic Information
VIS ID
TVIS10007317
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2109
Orient
+
Integrated sequence
TCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCT| |ACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGT
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1301025/1300910 (Hg38)
End
1301025/1300910 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-4635/Upstream/237936; hsa-mir-10397/Downstream/8400;
Nearest TSS
ENST00000502646/Upstream/5841; ENST00000605200/Downstream/20919;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/5055, chr5-CpG: 18/Downstream/34052
Nearby gene
TERT(-5863) ; MIR4457(+8400) ;
Upstream sequence
ggaggccgaggcaggtggatcacttgaggtcaggagtttgaaaccagcctggccaacatagtgaaaccctgtccctactaaaaatacaaaaattagccgg
Downstream sequence
GAGGTGCCTTGACTcctctccctctggcacacgcccgggtgggcgccatagctgctggcctgggtttgagcaggaggcttctgactccttgcattcccgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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