Basic Information
VIS ID
TVIS10007320
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1416
Orient
+
Integrated sequence
GCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGA| |CGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACC
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
91334435/92038618 (Hg38)
End
91334435/92038618 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/2021898; hsa-mir-103a-1/Downstream/1582078;
Nearest TSS
ENST00000502646/Upstream/655259; ENST00000511323/Downstream/43979;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/657505, chr5-CpG: 183/Downstream/1531915
Nearby gene
ARRDC3-AS1(-617903) ;
Upstream sequence
tggtagtttcttttgctgtgcagaagctctttagtttaatgagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
gtattcattggggtagcagaataataattaatatacaaaaataaataaatttcatttaacaaatgataactcattagaagacataatggaggagaagatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate