Basic Information
VIS ID
TVIS10007324
Fusion event
HBV-LOC105374873 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1441
Orient
+
Integrated sequence
CTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGC| |GCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTAC
Host Sequence
Chromosome
chr6
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
741410/741410 (Hg38)
End
741410/741410 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105374873
Nearest miRNA
hsa-mir-10398/Downstream/648904;
Nearest TSS
ENST00000381078/Upstream/29877; ENST00000607084/Downstream/20265;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/30113, chr6-CpG: 23/Downstream/146195
Nearby gene
EXOC2(-48269) ; LINC01622(+219831) ;
Upstream sequence
TTTCACTGGAAAGGTCCGTCAGGTGGTTTATTTGCTTTCCAATAAACCAGCTTTATTAGCTTAGAGTTGAATTTTTTAGATTACAAAAAGTGATCTTggt
Downstream sequence
aggagagtcagcctgtcttttgaagctttgaagcagatgttgacttcttctctctaactgtgaaagtcctggatgacatcttcttccaaaagaagcctgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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