Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007327
Fusion event
HBV-MAD1L1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
709
Orient
+
Integrated sequence
ATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAG| |GGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAAT
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
Start
End
2056887/2017252 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-339/Upstream/172999; hsa-mir-10399/Downstream/240263;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/2501, chr7-CpG: 17/Downstream/3020
Nearest cancer related gene
MAD1L1(TSG, No orient, 0)
Upstream sequence
tggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
CTGAACAAACAGGCGGCTGGCAGTGCTGACGGGGGCGTCCCAGACTCGCTTTAAGAAGCACCCAGCAGAGTTACATTGTCCACTGGCTGCTCCTCCTTAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.