VISDB Viral Integration Site DataBase

VIS ID

TVIS10007328

Fusion event

HBV-ATAD2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1821

Orient

+

Integrated sequence

TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA

Chromosome

chr8

Cytoband

q24.13

Reference genome

Start

End

124342024/123329784 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA8C ; FRA8E

Target gene

miRNAs that regulate target gene

hsa-mir-106b-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-941 ; hsa-mir-193b-3p ; hsa-mir-17-3p ; hsa-mir-372-3p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-3163 ; hsa-mir-4282 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-mir-93-5p ; hsa-mir-20a-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-20b-5p ; hsa-mir-520c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-520d-3p ; hsa-mir-302e ; hsa-mir-520e ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-520b ; hsa-mir-520f-3p

Nearest miRNA

hsa-mir-12123/Upstream/113921; hsa-mir-10400/Downstream/18250;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/54358, chr8-CpG: 101/Downstream/66068

Upstream sequence

aacttatttgtgatgtgtgtcctcaactaaaggacttgaacctttcgtttcatgcagtacttctggaacactgtttttgaagattgtgcatgcggatatt

Downstream sequence

ttaacccaatgaagtttgctaccattatcatcatcattttacagatgaagaaactaaggtacagagaggttaaatattctgtctaGACTAGATGCAGTAT