Basic Information
VIS ID
TVIS10007330
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1754
Orient
-
Integrated sequence
CATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGA| |TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCA
Host Sequence
Chromosome
chr8
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
137492720/136480477 (Hg38)
End
137492720/136480477 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1204/Upstream/1675532; hsa-mir-10400/Downstream/4252087;
Nearest TSS
ENST00000518652/Upstream/433430; ENST00000523232/Downstream/8971;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1022378, chr8-CpG: 119/Downstream/2016075
Nearby gene
KHDRBS3(-832872) ; FAM135B(+1649546) ;
Upstream sequence
gaaacttatttgtgacgtgtgtcctcaactaacggacttgaacctttcgtttcatgcagtacttctggaacactctttttgaagattctgcatgcggata
Downstream sequence
TAAAACTTGAATCCCAGGGATGTGAGCTATTAGACATCATTTGGAGATCACGGCCTTAGAGATCTTTTCCACATTTCTCCATATAAAGAGGGTAAGAAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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