Basic Information
VIS ID
TVIS10007331
Fusion event
HBV-LOC107986933 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2750
Orient
-
Integrated sequence
TTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATT| |TACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCA
Host Sequence
Chromosome
chr8
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
25640950/25783434 (Hg38)
End
25640950/25783434 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107986933
Nearest miRNA
hsa-mir-124-1/Upstream/437960; hsa-mir-10400/Downstream/1265419;
Nearest TSS
ENST00000518652/Upstream/6755; ENST00000522150/Downstream/56701;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/323922, chr8-CpG: 32/Downstream/256250
Nearby gene
CDCA2(-275525) ; EBF2(+58296) ;
Upstream sequence
tcgttggaaacgggatgcaatataaaaggtacacagcagcatactcagaaaatactttgccatatttccattcaagtcacagagtggaacattcccattc
Downstream sequence
ctcactgaaggaagtgatagggttggggttggggaggtactgacctaagtaactttggaaatgaatggagactggaagactaaagccatagtaactgcac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate