Basic Information
VIS ID
TVIS10007340
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
542
Orient
-
Integrated sequence
TTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCA| |AGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTA
Host Sequence
Chromosome
chr8
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
46839685/45928063 (Hg38)
End
46839685/45928063 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/3031788; hsa-mir-10400/Downstream/15786725;
Nearest TSS
ENST00000518652/Upstream/2731895; ENST00000518278/Downstream/894174;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/2650728, chr8-CpG: 41/Downstream/689304
Nearby gene
LINC00293(+912823) ;
Upstream sequence
caattatgcatttctcagaccatatcctcatcattaagtaatgcatgagtgACTGTGTGtcagtgaaaaggtgacatttgcgcagagttgaaggttggtg
Downstream sequence
tagagcaggtttgaaagactctttttggagtatctggaagtggacatttggagcgctttgtgaactatggtgaaaaaggaaatatcttccaatgaaaaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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