Basic Information
VIS ID
TVIS10007352
Fusion event
HBV-LOC101927141 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1942
Orient
-
Integrated sequence
ATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGG| |AGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCA
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
83827169/82914934 (Hg38)
End
83827169/82914934 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101927141
Nearest miRNA
hsa-mir-12123/Upstream/2673461; hsa-mir-10400/Downstream/8290551;
Nearest TSS
ENST00000518652/Upstream/2830; ENST00000522365/Downstream/43762;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1072693, chr8-CpG: 49/Downstream/1269590
Nearby gene
SNX16(-1072648) ; RALYL(+1268284) ;
Upstream sequence
tgtgcatgtgtctttatagcagcatgatttataatcctttgggtatatacccagtaatgggatggctgggtcaaatggtatttctagttctagatccctg
Downstream sequence
tttgttttttttttttttttttttttttttttttttttttttttttttttttgagatgcagtctcactctgtcacccaggctggagtgcaatggcatgat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate