Basic Information
VIS ID
TVIS10007355
Fusion event
HBV-DDX11L5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
409
Orient
+
Integrated sequence
AATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCT| |TCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCAC
Host Sequence
Chromosome
chr9
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
10988/10988 (Hg38)
End
10988/10988 (Hg38)
Orient
-
Location type
upstream
Target gene
DDX11L5
Nearest miRNA
hsa-let-7a-1/Downstream/19156;
Nearest TSS
ENST00000422679/Downstream/16669;
Nearest CpG islands
None/Target, None/Upstream, chr9-CpG: 64/Downstream/17861
Upstream sequence
tgacagagcaaggtcctgtctcaaaaaaagaccaaaacaaaCCAAAAGGCAACATGTGAAGGTACAAAGTGATATATGGAGAACAGTCTCTCTCATGATA
Downstream sequence
cagagaggcgcgccgcgccggcgcaggcgcagagaggcgcgccgcgccggcgcaggcgcagagacacatgctagcgcgtccaggggtggaggcgtggcgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate