Basic Information
VIS ID
TVIS10007359
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1821
Orient
+
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chr9
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
81498453/78883537 (Hg38)
End
81498453/78883537 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-2/Upstream/8073453; hsa-let-7a-1/Downstream/5086211;
Nearest TSS
ENST00000422679/Upstream/586394; ENST00000376525/Downstream/262137;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/585842, chr9-CpG: 280/Downstream/687027
Nearby gene
PSAT1(-553444) ; TLE4(+688425) ;
Upstream sequence
cctgggctccagcaaacctcccgcatcagcctccaagtagctagggctacaggcatgcatcagcaagcccagcttaaaaaaaaaaaatgctgtagagatg
Downstream sequence
aaaaaTTGttttttttttttttttttttttttttttGCCAGATCcccaaatgaggtaataatatcgtggctggatgtggcagttcatgccccagaggagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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