Basic Information
VIS ID
TVIS10007365
Fusion event
HBV-XRCC6P5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
+
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chrX
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
98858836/99603838 (Hg38)
End
98858836/99603838 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
XRCC6P5
Nearest miRNA
hsa-let-7f-2/Upstream/4540612; hsa-mir-105-1/Downstream/7035976;
Nearest TSS
ENST00000429181/Upstream/1029963; ENST00000485971/Downstream/692462;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/2918471, chrX-CpG: 23/Downstream/335498
Upstream sequence
acaatcttggctcactgcatcctctgccttccaggttcaagctattcttctgcctcagcctcctgagtagctgggactacaggcacgcaccaccatgccc
Downstream sequence
AAAAGTTGtttttttttttttttttttttttttttttttgagacagagtctcgctttgttgccaagctggagtgcagtggtgcatctgggctcactgtag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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