Basic Information
VIS ID
TVIS10007372
Fusion event
HBV-chrY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1727
Orient
+
Integrated sequence
GCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTA| |AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chrY
Cytoband
q12
Reference genome
GRCh37/hg19
Start
58888988/56701881 (Hg38)
End
58888988/56701881 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12120/Upstream/43222615;
Nearest TSS
ENST00000430575/Upstream/30973391;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/30074484, chrY-CpG: 36/Downstream/365764
Nearby gene
SPRY3(+211469) ;
Upstream sequence
tccattccgtttgattccagtccatccaagaaagttccattccagtccattgctttccagtccattccattccactctagtctattccactccattccct
Downstream sequence
cccttccattgcattccatactattccattccattcctttgcattccgtttccaatctattcgagtccattgcattccagtccaatccattcgattacat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate