Basic Information
VIS ID
TVIS10007384
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2063
Orient
+
Integrated sequence
CTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGC| |ACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGT
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
130664701/128866437 (Hg38)
End
130664701/128866437 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/3046615; hsa-mir-202/Downstream/976862;
Nearest TSS
ENST00000439456/Upstream/546223; ENST00000446589/Downstream/46442;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/156043, chr10-CpG: 98/Downstream/600247
Nearby gene
MKI67(-740233) ; MGMT(+600753) ;
Upstream sequence
TGCATACAGAAGTCTTGGCATTTCAACTCGTATTTCAAGGGCTGGGGGGGTAAATAAACAGGAACACCCGTGCCTTCCACAAATAATGGAAAGACAAAGA
Downstream sequence
CGGTGCAGAGATTGTCAGAGCCCTGAATACCTCCCTTAGAACTCAATGGAAAAAGGAAAAAGAAAGAAGAAAGAGAATGTGATGACAAAAATGTAATTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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