VISDB Viral Integration Site DataBase

VIS ID

TVIS10007387

Fusion event

HBV-LATS2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

110

Orient

-

Integrated sequence

CCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTC| |TCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGG

Chromosome

chr13

Cytoband

q12.11

Reference genome

Start

End

21552481/20978342 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-31-5p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-93-5p ; hsa-mir-181b-5p ; hsa-mir-135b-3p ; hsa-mir-107 ; hsa-mir-25-3p ; hsa-mir-223-3p ; hsa-mir-6801-5p ; hsa-mir-4697-3p ; hsa-mir-1256 ; hsa-mir-202-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-545-5p ; hsa-mir-4257 ; hsa-mir-6847-5p ; hsa-mir-183-5p ; hsa-mir-1182 ; hsa-mir-1178-5p ; hsa-mir-562 ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-548m ; hsa-mir-510-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-494-3p ; hsa-mir-574-5p ; hsa-mir-4789-5p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-181c-5p ; hsa-mir-3605-3p ; hsa-mir-3659 ; hsa-mir-4468 ; hsa-mir-759 ; hsa-mir-802

Nearest miRNA

hsa-mir-4499/Upstream/544496; hsa-mir-1267/Downstream/3184074;

Nearest TSS

Nearest CpG islands

None/Target, chr13-CpG: 551/Upstream/31917, chr13-CpG: 115/Downstream/9636

Nearest cancer related gene

LATS2(TSG, No orient, 0)

Upstream sequence

ATTAATTTAGGCTCCCTGGCCTAATAACCACATGCCCTGGTGGCTCACATGACCACCAGGGCATGTGAAAATTCCAAGGACTGTGTGTCAGTTGGTATGT

Downstream sequence

CCACAGAAGACTGCAGATTCTTAATTTCAATTCTCAGTTCAACCCTTAGTAACTCATTTCAGAAAGCAAATGGCTGTCATTTTAAAACTAATAATTTAGT