Basic Information
VIS ID
TVIS10007390
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1931
Orient
-
Integrated sequence
TCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGG| |AGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAG
Host Sequence
Chromosome
chr14
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
97552156/97085819 (Hg38)
End
97552156/97085819 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1260a/Upstream/1947833; hsa-mir-1185-1/Downstream/3023600;
Nearest TSS
ENST00000550708/Upstream/208429; ENST00000557745/Downstream/30536;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/51980, chr14-CpG: 74/Downstream/132903
Nearby gene
VRK1(-204205) ; LINC02291(+546828) ;
Upstream sequence
TGGTAAGATTAATGTacattttcaggacacttactatgtagccaggcactcttcaaagcaccttatatctattaataaactcatcaggacaactcggtgg
Downstream sequence
gaagcataggattgtcatgcttactttacagatgaagaaactgaggcacagagatgttgagtgaccagcctgaggtcatagtggtggtaagtgtcagaCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate