Basic Information
VIS ID
TVIS10007391
Fusion event
HBV-LINC00273 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
168
Orient
+
Integrated sequence
CTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATC| |ACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTT
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
33963342/34160875 (Hg38)
End
33963342/34160875 (Hg38)
Orient
-
Location type
upstream
Target gene
LINC00273
Nearest miRNA
hsa-mir-1225/Upstream/3266890; hsa-mir-11401/Downstream/2703;
Nearest TSS
ENST00000527434/Upstream/839; ENST00000319817/Downstream/818969;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/855, chr16-CpG: 203/Downstream/1020
Upstream sequence
cctcttggcgccccctcgatgctcttagctgagtgttccgcggcccaaagcgtttactttgaaaaaattagagtgttcaaagcaggtccaagccgcctgg
Downstream sequence
ataccgcagctaggaataatggaataggaccgcggttctattttgttggtttatggaactgaggccatgattaagagggacagctgggggcatttgtatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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