Basic Information
VIS ID
TVIS10007398
Fusion event
HBV-EGFEM1P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2340
Orient
+
Integrated sequence
AACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACT| |ACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGG
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
168450024/168732236 (Hg38)
End
168450024/168732236 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
EGFEM1P
Nearest miRNA
hsa-let-7g/Upstream/180287; hsa-mir-1224/Downstream/1690867;
Nearest TSS
ENST00000440867/Upstream/443683; ENST00000484765/Downstream/171130;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/481894, chr3-CpG: 39/Downstream/414006
Upstream sequence
atgcctgtaatcctagcactttgggaggccgaggcgggcggactgcttgagctcaggagtttgagaccagcctgggtaacacagtgaaaacccgtctcta
Downstream sequence
aagactgcaacacaataatagtaggggacttcaacacttgactttcatcaatgtacagatcacccaggcagaataccatcaagaaacattgaagttaaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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