Basic Information
VIS ID
TVIS10007399
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2368
Orient
+
Integrated sequence
GGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCC| |CTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTC
Host Sequence
Chromosome
chr4
Cytoband
q28.3
Reference genome
GRCh37/hg19
Start
132098510/131177355 (Hg38)
End
132098510/131177355 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5670048; hsa-mir-1305/Downstream/12166105;
Nearest TSS
ENST00000502981/Upstream/291714; ENST00000500169/Downstream/202658;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2083611, chr4-CpG: 27/Downstream/545837
Nearby gene
PCDH10(+1971960) ;
Nearest cancer related gene
PCDH10(TSG, +1971960) ;
Upstream sequence
tggtagtttcttttgctgtgcagaagctcttgagtttaattagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
CTTTATTTTTTGCAAGGTATACCTGAACTTGCATTAACATGATGGGTTATAACATAATATGTTATCATTGAATCTGGCCTCACAGCTTCAAAATTATACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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