Basic Information
VIS ID
TVIS10007400
Fusion event
HBV-LOC105377488 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2320
Orient
-
Integrated sequence
TGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCC| |TATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCG
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
152805043/151883891 (Hg38)
End
152805043/151883891 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105377488
Nearest miRNA
hsa-mir-12113/Upstream/4101223; hsa-mir-1305/Downstream/605436;
Nearest TSS
ENST00000502981/Upstream/84391; ENST00000507949/Downstream/7372;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/122752, chr4-CpG: 144/Downstream/651065
Nearby gene
GATB(-122868) ; FBXW7(+437367) ;
Upstream sequence
aggattccctatttaataaatggtgctgggaaaactggctagccatatgtagaaagctgaaactggatcccttccttacaccttatacaaaaatcaattc
Downstream sequence
TGCAGAGGCAGGAGTTTTGATGATGAAAAGACTACTTGAGATTCTTCTTTCTTTTCTCTTAGCTTCACCCAGCACTTACACATACACCCCGGTTCCCTCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate