VISDB Viral Integration Site DataBase

VIS ID

TVIS10007405

Fusion event

HBV-PRKG2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1897

Orient

-

Integrated sequence

GGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTT| |GGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGA

Chromosome

chr4

Cytoband

q21.21

Reference genome

Start

End

82035139/81113985 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-452-3p ; hsa-mir-548l ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p

Nearest miRNA

hsa-mir-12113/Upstream/4538359; hsa-mir-1243/Downstream/1639352;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/82331, chr4-CpG: 73/Downstream/100749

Upstream sequence

atttctgccttcttaataaatggtgctgggaaaactggctagccatatgtagaaagctgaaaccggatcccttccttacaccttatacaaaaatcaattc

Downstream sequence

TTTATGTTTGGTGTACAGATTCAGCTGAAATACCTAAGAGTATTTAGTAGAAGGTGGGCGAGATGAAGGGAAGACTTGCATACCCCAGGACAAACAGGAA