Basic Information
VIS ID
TVIS10007409
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2609
Orient
+
Integrated sequence
CCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAG| |TTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCC
Host Sequence
Chromosome
chr7
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
106412484/106772038 (Hg38)
End
106412484/106772038 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7F
Nearest miRNA
hsa-mir-10525/Upstream/4300507; hsa-mir-10399/Downstream/7881307;
Nearest TSS
ENST00000635602/Upstream/111042; ENST00000470135/Downstream/2973;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/110911, chr7-CpG: 58/Downstream/95574
Nearby gene
CCDC71L(-110850) ; PIK3CG(+93440) ;
Upstream sequence
ACACTCAGCATCATTTTCAATGCCATATTTCTTCGCTTCTGAAAAACCAACAAGCCAAAACTTGTCATGTGTAAGAGGGTAGTGATTTATTATTCAGAGC
Downstream sequence
atatcatatgatatatataatacatatattatatatatatcatataatatatataatacatatattatatatatatcatataatatatataatacatata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate