Basic Information
VIS ID
TVIS10007416
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1381
Orient
-
Integrated sequence
TCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCT| |GCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGA
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
150588334/151419862 (Hg38)
End
150588334/151419862 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRAXE ; FRAXF
Nearest miRNA
hsa-let-7f-2/Upstream/251536; hsa-mir-105-1/Downstream/538716;
Nearest TSS
ENST00000429181/Upstream/22658; ENST00000602419/Downstream/77864;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/22469, chrX-CpG: 98/Downstream/274845
Nearby gene
VMA21(-10498) ; PASD1(+143673) ;
Upstream sequence
tggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
ACAATTGCATGCAGCTGTTTCGATTCATCTTTAAAAGCTTATTTCCACAGCACATAACAAAGTTAATTAAATTGCTTTTTGAAGCAAGGCTGCTTTGTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate