Basic Information
VIS ID
TVIS10007418
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1789
Orient
-
Integrated sequence
GACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGG| |CATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGG
Host Sequence
Chromosome
chr1
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
175801905/175832769 (Hg38)
End
175801905/175832769 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1G
Nearest miRNA
hsa-mir-101-1/Upstream/3688125; hsa-mir-1182/Downstream/135601;
Nearest TSS
ENST00000473358/Upstream/88999; ENST00000457217/Downstream/44574;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/233097, chr1-CpG: 108/Downstream/373806
Nearby gene
TNR(-89153) ; COP1(+112062) ;
Nearest cancer related gene
COP1(TSG, +112062) ;
Upstream sequence
gtttctcatcaggctttaagagtctatcagtcttggctgggcatggtggctcatgcctgtaatcccagcactttgggaggctgaggtgggtggctcacga
Downstream sequence
ggtcaggagttcgagactagcctggccaacatagtgaaaccctgtctttaataaaaatataaaaaattagccaggcgtggtggcaggcacctgtaatccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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