Basic Information
VIS ID
TVIS10007419
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1793
Orient
-
Integrated sequence
GACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATA| |AATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGG
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
196155653/196186523 (Hg38)
End
196155653/196186523 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/3049940; hsa-mir-1182/Downstream/395890;
Nearest TSS
ENST00000473358/Upstream/125450; ENST00000496761/Downstream/241684;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3064429, chr1-CpG: 24/Downstream/422055
Nearby gene
KCNT2(+39260) ;
Upstream sequence
TCTGCCAGATCGATTTTGTTGTCGTTGTGGtttgagatggattcttgctctctttcccaggctagggtgcagtggtgctatctctgctcattgcaaactc
Downstream sequence
cacctcccgggatcaagtgattctcctgcctcagcctccaatagctgggattacaggcgcctgccaccgcacgcagctaatttttgtattttttagtaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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