Basic Information
VIS ID
TVIS10007420
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
217
Orient
-
Integrated sequence
TCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCT| |TGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCA
Host Sequence
Chromosome
chr1
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
208136119/207962774 (Hg38)
End
208136119/207962774 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/160251; hsa-mir-1182/Downstream/1469359;
Nearest TSS
ENST00000473358/Upstream/3482; ENST00000415754/Downstream/67529;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3002, chr1-CpG: 59/Downstream/547
Nearby gene
CD34(-51436) ; PLXNA2(+59469) ;
Upstream sequence
CTAGTGTGGGCCTTTCGTATTCTGGGTCAGATAAGTGAACAAGCAGGTGAGGTTCTGTGTGGGCTACCCTGGAATACAGTGTTGCATAGGGTTGTGTGAG
Downstream sequence
AGGTGCGGGGAACGCCTAGAAAACTTTGCAGGGAGAATGTTTTCTAAGCCAACACCTAGAAGACAAGCAAGAGTTTGCTGGGCAGAGAGTGAAGCTGGGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate