Basic Information
VIS ID
TVIS10007443
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2949
Orient
+
Integrated sequence
ATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACT| |TCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAG
Host Sequence
Chromosome
chr13
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
104623487/103971137 (Hg38)
End
104623487/103971137 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/1925133; hsa-mir-1267/Downstream/3560034;
Nearest TSS
ENST00000623511/Upstream/545937; ENST00000640578/Downstream/1494730;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1124724, chr13-CpG: 29/Downstream/2521923
Nearby gene
MIR548AS(-688639) ; DAOA-AS1(+1487919) ;
Upstream sequence
tttcattctgttttcctgaggaggagattgaagaacataaaagtgatctaccctgcccaagcaacacaactactatacattgctgctggattatagcccg
Downstream sequence
gctccgtttttttttttttttttttttttttttttttttttttttagatagagtcttgctttgtccccaggctggagtgcagttgcgtgatctcggctca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate