Basic Information
VIS ID
TVIS10007444
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2417
Orient
+
Integrated sequence
TCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCG| |TCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTT
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
End
30955268/30486062 (Hg38)
Orient
+
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-208a/Upstream/2852784; hsa-mir-1185-1/Downstream/528584;
Nearby gene
PRKD1(-558369) ; G2E3(+73061) ;
Upstream sequence
ACAAAATTATTCATTTGAAGGGTATCATAGAACAAAAAAAAAAAAACAGTACCAGTGGTCTGCATGGTTTTATTGACATGAGGAAGTATGCCAAAGAAAT
Downstream sequence
TCAGATGGCAAAATTGCTTTATTAGAGATTCTTTGGCCAAGAGAAAATAAAAACTTGAAAAAATTAAAACTAGCTCTCTTCAAGATACCCCAAATCTTGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate