Basic Information
VIS ID
TVIS10007449
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1436
Orient
-
Integrated sequence
TAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCG| |TCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTC
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
33899140/34096673 (Hg38)
End
33899140/34096673 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/3202688; hsa-mir-11401/Downstream/66905;
Nearest TSS
ENST00000527434/Upstream/120327; ENST00000319817/Downstream/63363;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/45430, chr16-CpG: 20/Downstream/37260
Nearby gene
RNU6-76P(-335897) ; LINC00273(+61912) ;
Upstream sequence
ccatttgattccatttgattcgattccatttgattccaatccattcctttcgattcaatttgattccattccattccattccactcccttcaactccact
Downstream sequence
ccactcctctccactccattccattccattccattccattccattccatttcactccattgcattccattcctttcttttgaaaggatatcactgtgtca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate