Basic Information
VIS ID
TVIS10007454
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1798
Orient
-
Integrated sequence
TGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTG| |GTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTG
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
19662280/19758967 (Hg38)
End
19662280/19758967 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/414393; hsa-mir-10226/Downstream/7534943;
Nearest TSS
ENST00000595228/Upstream/10024; ENST00000620112/Downstream/14957;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/13788, chr17-CpG: 128/Downstream/108026
Nearby gene
ALDH3A1(-10534) ; ULK2(+11863) ;
Upstream sequence
ctctactaaaaatacaaaatcaaccaggcatggtggcgggtacctataatcccagctacttgggagactgaggcaggagaatcacttgatcccgggaggc
Downstream sequence
agaggttgcagtgagccaagattgtgccactgcactccagcctggatgacagagcgaggctctgtctcaaaaaaaaaaaaaaaaggaaggaaatcctgac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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