Basic Information
VIS ID
TVIS10007458
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
439
Orient
+
Integrated sequence
CCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGT| |TGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGC
Host Sequence
Chromosome
chr17
Cytoband
q22
Reference genome
GRCh37/hg19
Start
55278554/57201193 (Hg38)
End
55278554/57201193 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/309838; hsa-mir-1250/Downstream/1130039;
Nearest TSS
ENST00000595228/Upstream/85060; ENST00000584476/Downstream/54658;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/114646, chr17-CpG: 124/Downstream/54514
Nearby gene
AKAP1(-79844) ; MSI2(+55377) ;
Upstream sequence
ttttaatttcctttaaagtacaagaaaaaTGAGTACAATAATAGTAATAATGAGTATATAATAATGAATCCAGGCTGGGTTACGTTGTCTCttttttctt
Downstream sequence
tttcttttttttgagtccgagtctcactctgtcgcccaggctggagtgcagtggcccaatctcgactcactgcaacctctgccacccaggttcaagcaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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