VISDB Viral Integration Site DataBase

VIS ID

TVIS10007462

Fusion event

HBV-MREG integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1787

Orient

-

Integrated sequence

ACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTA| |GGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTT

Chromosome

chr2

Cytoband

q35

Reference genome

Start

End

216852202/215987479 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-130b-3p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-106a-3p ; hsa-mir-122-5p ; hsa-mir-1307-3p ; hsa-mir-130a-3p ; hsa-mir-144-5p ; hsa-mir-301a-3p ; hsa-mir-301b-3p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-3666 ; hsa-mir-3925-5p ; hsa-mir-4295 ; hsa-mir-4430 ; hsa-mir-454-3p ; hsa-mir-4638-5p ; hsa-mir-4712-3p ; hsa-mir-488-5p ; hsa-mir-504-3p ; hsa-mir-589-5p ; hsa-mir-6812-3p ; hsa-mir-95-5p

Nearest miRNA

hsa-mir-10b/Upstream/2229320; hsa-mir-1244-1/Downstream/1913034;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/551342, chr2-CpG: 51/Downstream/25697

Upstream sequence

ggaattacaggtaagtgccatcacgcccggctaatttttgcatttttagtaaagaccgggtttcaccatgttggtcaggctagtctcaaactctggatct

Downstream sequence

cgtgagccacccacctcagcctcccaaagtgctgggattacaggcgttagccaccatacccggcAACATAAGCAACTTTTAAAAACTACATTACTTTTAT