Basic Information
VIS ID
TVIS10007464
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2860
Orient
+
Integrated sequence
ATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAA| |TCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAAC
Host Sequence
Chromosome
chr20
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
22186187/22205549 (Hg38)
End
22186187/22205549 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/3734858; hsa-mir-1-1/Downstream/4002637;
Nearest TSS
ENST00000382410/Upstream/151459; ENST00000439450/Downstream/15005;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/490843, chr20-CpG: 69/Downstream/362780
Nearby gene
LINC01432(-130895) ; LOC284788(+194784) ;
Upstream sequence
aaattgaaaacTATCTTCTATAaggttttgaatggttccaaacacatagaacagataaatactcaaagtgatggatacctcaaataccctgactttatca
Downstream sequence
ttacacattctatgtgtataacaaaatatcacatgtacccataaaaatgaatcacatatatgtaAAATGTTATGATTTAATACAAAGTAAAGAAATAAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate