Basic Information
VIS ID
TVIS10007468
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1375
Orient
-
Integrated sequence
CGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCC| |ATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGC
Host Sequence
Chromosome
chr21
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
10788024/10724431 (Hg38)
End
10788024/10724431 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10396a/Upstream/1736766; hsa-let-7c/Downstream/2681953;
Nearest TSS
ENST00000624081/Upstream/74596; ENST00000624445/Downstream/2292261;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/96707, chr21-CpG: 39/Downstream/2885184
Nearby gene
TEKT4P2(-819431) ; TPTE(+118719) ;
Upstream sequence
aggggaaggaatggaattgaacagacttgagtggagaggagtggattggaatgcaatagaatgaaatggaatggaatggagtggagtggagtggattgga
Downstream sequence
gtggaattaaatagaatggaatggaatggaatggaatggaatggaatggaatgaactcaaacggaatggactgcaagggaatggactggaatggaatgga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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