Basic Information
VIS ID
TVIS10007470
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1387
Orient
-
Integrated sequence
CCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGG| |CTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCT
Host Sequence
Chromosome
chr21
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
10801112/10711343 (Hg38)
End
10801112/10711343 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10396a/Upstream/1723678; hsa-let-7c/Downstream/2695041;
Nearest TSS
ENST00000624081/Upstream/61508; ENST00000624445/Downstream/2305349;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/83619, chr21-CpG: 39/Downstream/2898272
Nearby gene
TEKT4P2(-832519) ; TPTE(+105631) ;
Upstream sequence
tggaatggaatgaaatggagaggcgtgaagtggagtggagtgaattggagtggagaagaatggaatggaatggaatggaatggagtggagtggagtggaa
Downstream sequence
tggaagggaatggaatggataggaatggaatggagttgagggtataataatggaagaaaacggaatggaatggaatggagtggaatggagtggcatggaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate