Basic Information
VIS ID
TVIS10007472
Fusion event
HBV-IGL integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3036
Orient
-
Integrated sequence
CCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCC| |TTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCC
Host Sequence
Chromosome
chr22
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
22824389/22470052 (Hg38)
End
22824389/22470052 (Hg38)
Orient
-
Location type
Intronic
Target gene
IGL
Nearest miRNA
hsa-mir-1286/Upstream/816667; hsa-let-7a-3/Downstream/352724;
Nearest TSS
ENST00000624155/Upstream/19850; ENST00000407120/Downstream/19416;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/246533, chr22-CpG: 69/Downstream/38253
Nearby gene
BMS1P20(-147065) ; ZNF280B(+14383) ;
Upstream sequence
TATGAATGATACATCTAACATAAAGCAGACACTGGATATTGGTGTGGTGAGTGAAAACACTCAGGCTTGTATGTATGTAGATTCCTCTCCCACAGAGGGC
Downstream sequence
AGTCATCAATATTACCAACTCAACTAAGAGGATGATTCTTATTTGGTGCAGTTTCTCTAATTCCAAGAGCAGTGGAGAAGTCTAATACCAGGGCAGTGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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