Basic Information
VIS ID
TVIS10007473
Fusion event
HBV-IGL integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr22
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
22824422/22470085 (Hg38)
End
22824422/22470085 (Hg38)
Orient
-
Location type
Intronic
Target gene
IGL
Nearest miRNA
hsa-mir-1286/Upstream/816700; hsa-let-7a-3/Downstream/352691;
Nearest TSS
ENST00000624155/Upstream/19883; ENST00000407120/Downstream/19383;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/246566, chr22-CpG: 69/Downstream/38220
Nearby gene
BMS1P20(-147098) ; ZNF280B(+14350) ;
Upstream sequence
GGATATTGGTGTGGTGAGTGAAAACACTCAGGCTTGTATGTATGTAGATTCCTCTCCCACAGAGGGCAGTCATCAATATTACCAACTCAACTAAGAGGAT
Downstream sequence
GATTCTTATTTGGTGCAGTTTCTCTAATTCCAAGAGCAGTGGAGAAGTCTAATACCAGGGCAGTGAGCACGACCATCTGAACAACTCTTCCTTTTATGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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