AHRR _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007479
Fusion event
HBV-AHRR integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
532
Orient
+
Integrated sequence
TTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGA| |CTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGG
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
318225/318110 (Hg38)
End
318225/318110 (Hg38)
Orient
-
Location type
Intronic
Target gene
AHRR
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26a-5p ; hsa-mir-18a-5p ; hsa-mir-125b-5p
Nearest miRNA
hsa-mir-10397/Downstream/744786;
Nearest TSS
ENST00000502646/Upstream/9913; ENST00000504625/Downstream/3649;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/8089, chr5-CpG: 209/Downstream/2563
Nearest cancer related gene
AHRR(TSG, No orient, 0)
Upstream sequence
tggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
ccgcaccctgcacctcccacccttaccctgcacctctccccatcttttacctccctcccaccctgcatctccccccaaccctgcacctccccccatcctt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate