Basic Information
VIS ID
TVIS10007484
Fusion event
HBV-LOC105375638 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
104
Orient
+
Integrated sequence
CCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTAC| |TGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAG
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
93425174/92412946 (Hg38)
End
93425174/92412946 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375638
Nearest miRNA
hsa-mir-12123/Upstream/1207387; hsa-mir-10400/Downstream/616805;
Nearest TSS
ENST00000518652/Upstream/309660; ENST00000522531/Downstream/699;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/268534, chr8-CpG: 56/Downstream/552619
Nearby gene
RUNX1T1(-309720) ; FLJ46284(+300016) ;
Upstream sequence
gtttgaattttcaAGTCATCCTTTTAATATATTAATATACAATACATGAATAATTTATGTATTCATGCCACGAACAATTTCTTTCTTTAATTAAATTAAG
Downstream sequence
CATGAGCTACAGTTGAGACAGACGAGCTGGCTGGTTTTCTGTTTTGATATTGTCTGGAGAAAAAGAACAAAGACCCCTTAACTCAACCTGTATCTTACTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate