TBC1D2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007485
Fusion event
HBV-TBC1D2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1789
Orient
-
Integrated sequence
GACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGG| |CATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGG
Host Sequence
Chromosome
chr9
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
100997271/98234989 (Hg38)
End
100997271/98234989 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBC1D2
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-17-5p
Nearest miRNA
hsa-let-7a-1/Upstream/5772; hsa-mir-12126/Downstream/8365939;
Nearest TSS
ENST00000422679/Upstream/5906; ENST00000610463/Downstream/20591;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/42106, chr9-CpG: 96/Downstream/20111
Upstream sequence
ataagtacaaaaagaactttcctcaacacaattatagccatatataaaatgcccatggctaacattataatcaaatgtggaaaaactgagagctttccct
Downstream sequence
ggtcaggagttcaagaccagcctggccaggatggtgaaaccccgtctctactaaaaatacaaaaattagccgggcgtggtggcgcatgcctgtagtccca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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