DENND1A _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007486
Fusion event
HBV-DENND1A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1789
Orient
-
Integrated sequence
GACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGG| |CATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGG
Host Sequence
Chromosome
chr9
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
126229718/123467439 (Hg38)
End
126229718/123467439 (Hg38)
Orient
+
Location type
Intronic
Target gene
DENND1A
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-98-5p
Nearest miRNA
hsa-let-7a-1/Upstream/64836; hsa-mir-12126/Downstream/18090;
Nearest TSS
ENST00000422679/Upstream/5416; ENST00000458025/Downstream/24445;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/75156, chr9-CpG: 109/Downstream/532008
Upstream sequence
gtcccctagcctgacacccataaagggtctgtgctaggaaggattagtaaaagaggaaggcctctttgcagttgaggtaagaggaaggcatctgtctcct
Downstream sequence
ggtcaagagatggagaccatcctggccaacatggtgaagccccatctctactaaaaatacaaaaaattagccaggcatattggcgggcgcctgtaatccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate