Basic Information
VIS ID
TVIS10007494
Fusion event
HBV-CTXND2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1602
Orient
+
Integrated sequence
CTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGC| |ACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAG
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
150871613/150899137 (Hg38)
End
150871613/150899137 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
CTXND2
Nearest miRNA
hsa-mir-101-1/Upstream/347123; hsa-mir-1182/Downstream/646659;
Nearest TSS
ENST00000473358/Upstream/12001; ENST00000463774/Downstream/27126;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/269412, chr1-CpG: 21/Downstream/27006
Nearby gene
ARNT(-22369) ; SETDB1(+27202) ;
Upstream sequence
cagtgagctgagatcacgccactgcactccagcctgggcgacagagcaagactccgtctcaaataaataaataaataaataaataaataaataaacaaac
Downstream sequence
aaacaaTAATAAACTCAAAAAGTccaagcatggtggctcacgcctgtaatcccagtgccttgggagggctaggtgagaggatcacttgaggccagaactt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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