Basic Information
VIS ID
TVIS10007497
Fusion event
HBV-LOC112267957 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1307
Orient
+
Integrated sequence
CTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGC| |AGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCC
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
41455668/41487930 (Hg38)
End
41455668/41487930 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
LOC112267957
Nearest miRNA
hsa-mir-1236/Upstream/2413549; hsa-mir-10398/Downstream/110793;
Nearest TSS
ENST00000381078/Upstream/152079; ENST00000416951/Downstream/14514;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/17074, chr6-CpG: 130/Downstream/15890
Nearby gene
NCR2(-137043) ; FOXP4(+58496) ;
Upstream sequence
gatagtatctcattgtggttttgatttgcatttctctgatggccagtgatgatgagcattttctcatgtgtctgttggctgcataaatgtcttcttttga
Downstream sequence
GGCACCAACCCAAAGCCCCAGTCTCTAGATGTGGGTGGCATTAAGGCCTGGGGGGGAGAGCAGCTGACACATACCCCACTGTAAACACCTGGCAAGGAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate