Basic Information
VIS ID
TVIS10007502
Fusion event
HBV-SRGAP2B integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2018
Orient
+
Integrated sequence
ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG
Host Sequence
Chromosome
chr1
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
144039515/144969590 (Hg38)
End
144039515/144969590 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA1F
Target gene
SRGAP2B
Nearest miRNA
hsa-mir-101-1/Upstream/27874862; hsa-mir-1182/Downstream/880997;
Nearest TSS
ENST00000473358/Upstream/14144; ENST00000400889/Downstream/123656;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/85555, chr1-CpG: 264/Downstream/123396
Upstream sequence
tggtagtttcttttgctgtgcagaagctctttagttttatgagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
gtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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