Basic Information
VIS ID
TVIS10007503
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1130
Orient
-
Integrated sequence
TACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAA| |CAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATC
Host Sequence
Chromosome
chr1
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
149051123/143556454 (Hg38)
End
149051123/143556454 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1F
Nearest miRNA
hsa-mir-101-1/Upstream/26461726; hsa-mir-1182/Downstream/2294133;
Nearest TSS
ENST00000473358/Upstream/55942; ENST00000443018/Downstream/179612;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/57546, chr1-CpG: 76/Downstream/86434
Nearby gene
LSP1P5(-98069) ; LINC02591(+228353) ;
Upstream sequence
AAGAACAGTCCTAATGATATCATTTGAAAAGGCCTCTAATATTGTCAGTGATACATACTGACAACCCATTCAGCCCAATGTAGCAGGCAGTCTGCTCCCA
Downstream sequence
CCCTGACCCTTTCCCTAGTGACATCTGGCTCTCAGCTTATTGCCCTTTCATTTAATTTTCATAAATCCTGATTTAGTTTCCTGATTTTCTAAAGAGAAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate