Basic Information
VIS ID
TVIS10007505
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2326
Orient
-
Integrated sequence
ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
150331854/150359378 (Hg38)
End
150331854/150359378 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1F
Nearest miRNA
hsa-mir-101-1/Upstream/1971015; hsa-mir-1182/Downstream/132967;
Nearest TSS
ENST00000473358/Upstream/10694; ENST00000369067/Downstream/3713;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/37687, chr1-CpG: 16/Downstream/4977
Nearby gene
PRPF3(-6150) ; RPRD2(+5136) ;
Upstream sequence
ggcggtcaaggtgggcggatcatgtgaggtcaggagttccagaccagcctggccaacatggcgaaaccctgtccctactaaaaatacaaaaattagccgg
Downstream sequence
gcatggtggcacatgtctgtaatcccagctacctgacatgctgaggcaggagaattgtttgaacccaggaggctgaggttgcagtgacctgagatcctgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate