Basic Information
VIS ID
TVIS10007506
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2275
Orient
-
Integrated sequence
AATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGT| |GGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAG
Host Sequence
Chromosome
chr1
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
171440457/171471318 (Hg38)
End
171440457/171471318 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/369512; hsa-mir-1182/Downstream/667480;
Nearest TSS
ENST00000473358/Upstream/136792; ENST00000463586/Downstream/14233;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/806281, chr1-CpG: 56/Downstream/14060
Nearby gene
FMO4(-129234) ; PRRC2C(+14209) ;
Upstream sequence
ggaggccgagacgggcggatcacttgaggtcatgagtttgagaccagcctggccaacatggtgaaaccctgtccctactaaaaatacaaaaattagccgg
Downstream sequence
gcatggtggtgggtgcctgcagtctcagctactagggaggctgaggcatgagaatcacgtaaatccttgaggtggaggttgcagtgagacaagatcatgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate